Have kids. Your main problem then is to feed them, keep them clothed, keep them relatively happy, and educate them (all surprisingly non-trivial problems with lots of learning along the way, especially the last two). Pursue career goals as much as possible, but conditional on having acceptable solutions to kid problems mentioned. Simplifies things, and provides a good option in case of failure on work problems (“Work today sucked, but at least I’ve got these great kids!”). Constraints can be good!