The "machine for living" philosophy is intended to be ergonomic, but is extremely rigid and therefore as soon as there are unanticipated needs it ends up anti-ergonomic.

There is also a great tendency for modern architecture to be selected purely based on looks, which produces all kinds of strange anti-egonomic disasters. Libraries that echo. Office blocks that focus the sun onto random burning spots on the street.

Then there's the effect of anti-ornamentation on the human psyche. I seem to remember that one of the modernist car parks in Britain was demolished partly because too many people were committing suicide from it.