The Annoying Site doesn't do anything if viewed without JavaScript --- showing that JS is responsible for the majority of annoyances. Unfortunately a lot of users are reluctant to use whitelist-based JS enabling, but IMHO it is extremely effective and well suited to those who mainly use the Internet as a hyperlinked document library.

(I discovered the effects of turning off JS a long time ago, and have been whitelisting since. It makes using the Internet much less irritating.)