Your mileage may vary but it's also a common issue having to filter out empty items out of something like ",foo,bar ,,,,baz,,xyzzy," where you only really want those four words. You will especially encounter this in parsing user input which might have extra whitespace, or badly formed lists of items.
Use strtok() to split C strings into tokens delimited by the given set of delimiters. If you want to catch each comma but skip over any whitespace and split at the first '=' only, then use something else.
Let's say if I'm going to need a configuration file for my program I'd most certainly start with something I can parse with strtok(). I would really need very specific needs to warrant a more complex format that would require a more sophisticated parser in which case using one would be a no-brainer.
(Yes, those could be valid inputs, but if they are, chances are they should be parsed differently)