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Re:Show HN: Vaex - Out of Core Dataframes for Python and Fas... by ah- on Friday December 14, 2018 @09:32AM (#18681028)
I'll need to have a closer look later, but would vaex fit in with somewhat indexed mapped files?

E.g. parquet supports column indexes now: https://issues.apache.org/jira/browse/PARQUET-1201

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