I have tried both with quite complicated applications and I have to say that I prefer tailwind.

With PostCSS in your pipeline, you can add the tailwind plugin and start composing CSS. This way, you can use your configuration even in places where you are required to write CSS (e.g. for transitions or media queries):

    @screen xs {
      .item {
        @apply border-b border-blue-darker;
        transition: background-color 0.2s;
      }
    }