I was thinking of this from the other way around, of adding piloting capabilities to an autonomous mission; you now need to adding a bunch of specialized equipment to keep the meatbags inside the spacecraft happy. I’m not sure which way the Soviet shuttle was designed: primarily human-piloted, with optional autonomy added as an afterthought, or meant to be pilotless but with people were added later. It’s the latter case I was concerned about, but I realize now that you’re talking about the former.