I was up and running with the Ergodox EZ Glow within a day, I did fiddle around with the key layout for awhile but it's settled into place for me pretty quickly.

It's dramatically more comfortable and I would never go back to a stock tenkeyless. I held out for an Infinity for a long time, then EZ added addressable LEDs and the difference between it and the Infinity now consists of things I don't plan to use.