That's what I use at work, I just wrapped it with Vue and did some moderately horrible stuff internally to allow reactive rendering (and by moderately I mean horribly).

Performance is solid, it's easy to work with for ~90% of the times I use it and there are other ways to handle that last 10%.

I probably wouldn't have used datatables on greenfield but the legacy (in every sense) project I inherited already used it so I went with it anyway.