And throwing pills at it doesn't seem to help either - we've had weight loss pills for decades, unless THIS round is going to work.

Many of the most effective medications were banned due to medical risks --- for example, DNP. Efficacy isn't in doubt here; safety is. IMHO, given that all other public health interventions have failed, we should relax the safety constraints on these existing medications and mitigate the risks however we can. Demanding perfection in drug development has left us with nothing, and something is better than nothing.

"Acute oral exposure to DNP has resulted in increased basal metabolic rate, nausea, vomiting, sweating, dizziness, headache, and loss of weight. Chronic oral exposure to DNP can lead to the formation of cataracts and skin lesions and has caused effects on the bone marrow, central nervous system, and cardiovascular system.

...

Case reports have shown that an acute administration of 20–50 mg per kilogram of body weight in humans can be lethal. The lowest published fatal ingested dose is 4.3 mg/kg. Concerns about dangerous side-effects and rapidly developing cataracts resulted in DNP being discontinued in the United States by the end of 1938. DNP, however, continues to be used by some bodybuilders and athletes to rapidly lose body fat. Fatal overdoses include cases of accidental exposure, suicide, and excessive intentional exposure (overdose). The substance's use as a dieting aid has also led to a number of accidental fatalities."[1]

I would argue that's an entirely unsafe medication. That's not a drug that's short of perfection, it seems to be the sort of medication that will solve the obesity crises by actively killing people instead.

[1] https://en.wikipedia.org/wiki/2,4-Dinitrophenol