I totally agree. I was 35 when I worked for a start-up, by that time I didn't have kids, health issues, sick family members nor midlife crisis. Work side of life was tough but rewarding at the same time. Lots of pressure, but I could smile in the end of the day.

Now I am a managing partner in 3 companies and have all the issues above. Work is ok, manageable, but the personal issues are REALLY hard to cope with, specially the irreversible ones related to aging and health.

It the past, resilience was a key attitude to me. Nowadays I see acceptance as being more important.