I use Fedora. Most of my issues seem like potential leaks/performance degradations in the accessibility stack. Performance drops over time, and doesn't seem to improve when apps are killed/restarted. The only components I can't restart are a11y-related, and the only way to get performance back is to restart or log back out and in. Maybe the issue is gnome-shell, but I can't help but feel like there'd be a revolt if everyone experienced the performance issues I do, so unfairly or not I blame accessibility.