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A comment on Israeli scientists develop tissue implants that won't be rejected. Parent comment

Re:Israeli scientists develop tissue implants that won't be ... by trhway on Tuesday November 20, 2018 @02:49AM (#18492407)
>decellularized pig ECMs

why not 3d print the ECMs? Isn't it just basically collagen with some fibrin/laminin thrown into? Do the decellularized ECMs not have any immunogens left? Definitely isn't an issue with the printed ones.

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Re:Israeli scientists develop tissue implants that won't be ... by claytonius on Tuesday November 20, 2018 @04:12AM (#18492667)
Unfortunately even with just collagen we can see an immunogenic response that is annoyingly exacerbated by UV cross-linking of the individual collagen proteins. That's why many of the best manufactured ECMs are cross-linked using a mixture of UV exposure and EDC-NHS. Without photolithography i'm not sure you'd be able to get a resolution high enough to mimic native ECM structures.
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