My pet theory is that there are several conditions that look like "depression", one of them is produced by the body to prevent self-harm resulting from acute anxiety. This theory has two important consequences:
1) Trying to ease certain kinds of depression via medication or other direct-action tools is likely to cause unintended side-effects (self-harm, anxiety, mania) that the depression was there to prevent.
2) The body will fight back against any direct intervention, trying to reinstate control over unbalanced psyche, e.g. building up tolerance to medication. A more fruitful approach would be to locate and eviscerate the underlying anxiety-inducing problem; the depression should then lift on its own accord.
Like I said, it's just a pet theory, but it leads itself to validation.