This is taken significantly out of context. From what I recall (and I could be wrong, it was a while ago), in the book he explains that those startups that "follow" others by imitating the first movers have a harder time becoming successful (those are the "losers"). This is because the first mover tends grab the most market share. When he says that monopoly is the goal, he argues that the best startups create something really hard to replicate, obtain a lot of market share, and then become hard to compete with.It can be interpreted in many ways, but I didnt get from the book that he was in favor of monopolies.