The importance of a plug-in bus like the S100 was a crucial insight that enabled the PC revolution, and the first wave of the microcomputer revolution happened mainly due to bus compatibility. Eventually, Apple and IBM also used plug-in buses which were essentially simplified or smaller versions of the S100, using signals from the 6502 and 8088 instead.
The 16-bit extension of the IBM PC plug-in bus became known as ISA, and ensured its enduring domination even to this day (it's still around as the X-bus inside modern highly-integrated Southbridge ASICs, though it's no longer brought out as an external plug-in bus, except in some legacy industrial PCs).
Interesting to hear that.... I've recently been reading through old issues of DTACK Grounded, and Hal Hardenberg said similar things, and at length, about the reliability improvements you get with static memory over dynamic. (A few years in, he was also selling dynamic memory products, presumably for scale, and was no longer able to ground DTACK in his designs.)
I am truly sorry that his life was ended by this latest fire disaster.