Not OP but my remote setup is a home office on a separate floor from the family. The kids are in Jr High / High School but they know they aren't allowed to bother me during work hours once they get home.

The separation from family is important. I get the benefits of working from home: complete control over my environment, no pointless small talk, no time wasted driving 90 minutes into the city, etc. But I also get the full benefit of having an office to myself without interruptions.

I imagine this would not work if I didn't live in an area with cheap housing. I'm in suburban Atlanta.