Personally, I think SF is a great place to live. It has great weather, lots going on, decent public transportation, lots of tech, and more open mindedness about how people want to live their lives. Other than issues that are pretty much inherent to living in a city (less access to large grocery stores, inability to setup a workshop in my home) the only big complaints I can think of are the cost of living, aggressive homeless people, and how crazy the DMV is.