ITER has full remote handling as it's expected to get extremely radioactive. Scaling reactors up does not really mean increasing the neutron load on the walls as you want to keep that fairly steady per surface area.
Tritium production has ~zero impact on operation. The breeding blankets are really simple, you take lithium and enclose it in a metal of some type. Replace after a few months.
Also, a ~10x device is unlikely to be 50-50 DT as while hard to operate on pure DD fusion it's not that hard to get when you have some tritium in the mix.
It's not designed to replace everything, but I doubt commercial designs would go that far either.
They've already tested joints in the REBCO tape, and found that they introduce very little electrical resistance.
As you scale up the power of a fusion reactor, the volumetric power density goes DOWN. This is because it becomes limited by the power/area through the first wall. Square/cube law in action.