"Modern meanings of the terms science and scientists date only to the 19th century. Before that, science was a synonym for knowledge or study, in keeping with its Latin origin. The term gained its modern meaning when experimental science and the scientific method became a specialized branch of study apart from natural philosophy.
From the mid-19th century, when it became increasingly unusual for scientists to contribute to both physics and chemistry, "natural philosophy" came to mean just physics... chairs of Natural Philosophy established long ago at the oldest universities are nowadays occupied mainly by physics professors. Isaac Newton's book Philosophiae Naturalis Principia Mathematica (1687), whose title translates to "Mathematical Principles of Natural Philosophy", reflects the then-current use of the words "natural philosophy", akin to "systematic study of nature". Even in the 19th century, a treatise by Lord Kelvin and Peter Guthrie Tait, which helped define much of modern physics, was titled Treatise on Natural Philosophy (1867)."
https://en.wikipedia.org/wiki/Natural_philosophy#Origin_and_...
I guess I bother making the point, because that history was surprising to me when I first learnt about it.
Karl Popper obviously didn't create the method out of whole cloth, but the ideas he formalized & championed became a real platform. Nearly any scientist/science advocate (degrasse tysson, dawkins..) dealing with an "is this science" question paraphrases him Popper.