I suppose that you are familiar wuth analog modular synthesizers. There is a demand for these, even though they become very expensive toys fast. But musicians seem to like the flexibility and room for experiments that they allow. Even software simulations of these synths are pretty successful. VCV Rack (http://www.vcvrack.com) is a recent open source emulation of eurorack synthesizers that has found a following fast.

If you are interested in providing procedural audio for games, you should take a quick look at what WWise provides in that area. I have not had time to do that myself, but from what I have seen it provides a lot of features for controlling sound and music based on the current game situation. It is also a pretty expensive package.

Edit: corrected link. Thank you striking!