I always feel a bit sorry for the rubber stamp monkeys sitting at the border control in the US. They are so fucked at so many levels that isn't funny any more. For starters, their job is purely symbolic as it is unlikely anyone that shouldn't be there would get that far: it would imply multiple levels of failure in several agencies: you traveled internationally and were profiled, checked, and triple checked before you even arrived at your gate. They are bureaucratic ass coverage with little practical real life value. What little value there is has more to do with controlling migration than any security.

Domestically, many airlines already have automated checkins (including luggage dropoff in some places), automated boarding, and in some places automated passport checks at immigration. The last human hurdle is security screening, which is mostly theater at this point.

So, automated screening of travelers at the beginning of their journey makes a lot of sense. Mostly it's just confirming the obvious: are they who they claim they are (i.e. does the person showing up match the automated profile available already, are there any red flags warranting extra attention) and are they carrying anything they should not be carrying. Like AI already outperforming physicians in the job of scanning medical images for anomalies, surely state of the art luggage scanners are also outperforming humans (probably by magnitudes). Add to that some screening for clear markers that somebody's behavior is a bit off and you have basically automated away security staff likely to miss those signals because they are human beings that get tired, stressed, bored, distracted, biased, etc.

So the combined checks of identity, profiling, automated luggage scans and escalation to humans in case of any doubt should be vastly more efficient. The default case should be zero humans involved with the whole process. When it escalates, you still get the humans in the loop that are then a lot more effective because they already know there were some red flags.

This stuff will initially perform quite poorly probably. But it will still be worth it in identifying the "definitely not lying, don't waste your time on this" category of travelers.