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Re:Aptoide wins court battle against Google in landmark case by wedlled on Wednesday October 24, 2018 @05:50AM (#18290975)
As per their 'About page' no difference: "The original F-Droid client app was based on the Aptoide app developed by Roberto Jacinto."

F-Droid is a fork of the original Aptoide project, it seems.

Re:Aptoide wins court battle against Google in landmark case by ptx on Wednesday October 24, 2018 @07:04AM (#18291300)
It was forked in 2010, so the the differences after 8 years of separate development are probably quite significant. (But both clients let you add third-party repositories, so in that regard there is no difference.)