Nuitka is awesome. I used it to compile a Python command line tool recently and it worked fine. In fact, it worked so well that I added a Nuitka build script to that project... But Nuitka is written and maintained by a single person [0]. I think for such a huge task (with so many edge cases) it needs more attention/support in order to become mainstream.

[0]: https://github.com/Nuitka/Nuitka/graphs/contributors