A kind of a problem with "LSD-like" psychedelics (seemingly doesn't apply to "meth-like" MDMA) as well as with the weed is the experience with them depends hugely on your pre-existing vision, what do you actually want and where do you drive yourself during the trip. If you are a kind and loving person by nature (even if depressed and confused at the moment) sensations of beauty, joy and love will probably overwhelm you and you'll end up happy and kind but if you're a psycho like Manson you end up even more psycho. If you consciously stick to the positive emotions and vision during the trip the trip is going to be amazing and may have a profound positive therapeutic effect, but if you stumble upon fear or sorrow inside you and don't know you can and should consciously choose positive emotions it can be nightmarish. I only know of one tryptamine (5-MeO-DMT) and one rare Hungarian mushroom (can't even remember the species name now, perhaps I'll add it later) that seem to always yield positive experience, with all the others one should never forget to "use the steering wheel" during their trip. One can rely on the setting and the sitter instead but I believe this is less reliable and people should really learn basic compassion meditation and being mindful about their feelings before trying psychedelics).