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Re:How to use 1000 registers (1979) [pdf] by kccqzy on Saturday September 29, 2018 @03:12AM (#18099105)
Sounds like the reverse problem is easier: pretending there are many registers and let the toolchain figure out how to spill them to memory.
Re:How to use 1000 registers (1979) [pdf] by rwmj on Saturday September 29, 2018 @04:48AM (#18099353)
There was an odd platform in the 80s/90s which did this called Taos. Its virtual machine had up to 5x65535 registers.

https://news.ycombinator.com/item?id=9806607