It seems unreasonable to expect any human to be able to reasonably predict anything 10+ years into the future with the kind of accuracy needed to provide climate change impacts of a given area. Only easy one is probably water levels rising causing places next to the ocean to go underwater.

Buy at a decent altitude, higher up than surrounding areas where water can drain into, and that has access to a water and food source which seem resilient. But who knows when a fire or flood or earthquake or whatever will come ruin your plan.