Re:The Omnigenic Model as Metaphor for Life
by waserwill on Saturday September 15, 2018 @12:02AM
(#17992917)
This is indeed a massive problem with GWA (genome-wide association), since the studies only see additive variation. Lot of interesting techniques around to look at non-additive variation. Had acquaintances working on drug-drug interactions and the genetics of skin colour; had to find some cool workarounds.
On the other hand, given that height is closely linked to metabolic conditions, and both the transcription/translation rate and functioning of every cellular component relies on metabolism, it doesn't take long for changes to propagate to simple traits like height.
On the other hand, given that height is closely linked to metabolic conditions, and both the transcription/translation rate and functioning of every cellular component relies on metabolism, it doesn't take long for changes to propagate to simple traits like height.