Cython also supports writing type annotations in a separate .pxd file. It's a bit awkward because you're effectively duplicating all function + variable declarations, but it _is_ a valid way to keep the original Python source intact.

(On a side note, using this feature led to a particularly memorable debugging session that set a personal record in terms of time spent vs amount of code changed to fix the issue: https://news.ycombinator.com/item?id=11115110 ).