Tho its predominantly males there are many women who are leading or lead large businesses. Meg Whitman for example, lead eBay from 30 employees to 15000.

The unique feature of Holmes was that she was the first woman starting and leading a (supposedly successful) start-up. Needless to say though, it was a facade. That's saddening, but having read Bad Blood I expected nothing less but the company Theranos to dissolve.