It's also wrong to assume that just because a company gets acquired, that there's going to be 'unnecessary levels of administration and other associated costs' that are just begging for the ax. Pharma companies have finance people too that can provide that kind of oversight and recommendations.
The market for drugs is complicated by two factors. First is that people who need drugs generally can't get that need met by any other product / service. So there's an incentive for price creep. Second is the patent system which forces companies to grab as much cash as they can until the patent expires.
If longer patents were granted, or the patent system were more sane in that the patent period doesn't begin until after the drug is able to be made available to the market, then the costs of developing drugs would be a lot more legible, and therefore amortizable.
Also are you seriously arguing here for longer patent terms? You think that will get new products to market more quickly?
"Orgs have an incentive not to respond yes to every request they get" - not true. Orgs have an incentive to reduce the cost of saying yes, but saying yes is an important part of providing good customer service, keeping repeat business, and building a brand that enables bigger growth. Orgs that lose sight of this, deserve to be eaten by their competitors.