After switching back and forth between Dvorak and QWERTY for multi-hour work sessions maybe three times I found that I could do so instantly. I learned touch typing on QWERTY very young so maybe this is why it was easy for me. I often use a keyboard without any labels on the keys so it's always touch typing no matter the layout I pick. Also, I don't really get anxious about things that slow down my text entry, so I tolerated my own interface experiments without worry. I've coded and done data analysis using my thumbs on a cell phone. Switching keyboard layouts really isn't so bad by comparison. To each their own.

I find it surprising that much of the current effort in keyboard layouts is in finding things that are better than QWERTY but similar enough to it to not be scary. I am completely unmotivated by this. If someone could convince me that their layout was a kind of super-Dvorak, and scientifically enhanced the same features that I enjoy about it then I would try it out in a heartbeat.