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A comment on A constant loud clicking or crunching noise in her head stumped doctors. Parent comment

Re:A constant loud clicking or crunching noise in her head s... by riahi on Sunday August 19, 2018 @07:58PM (#17796897)
The Human Leukocyte Antigen complex is a protein complex that immune cells use to determine self from non-self cells. There are many many many possible alleles, some of which are thought to be defective and contribute to auto-immune disorders. The most notorious (for medical students studying for standardized tests) is HLA-B27.

https://en.wikipedia.org/wiki/HLA-B27

Specifically, check out the section on disease associations.

And

https://en.wikipedia.org/wiki/Human_leukocyte_antigen

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