Whether this matters or not will depend on the what your application is doing and how many users you have. For example, if your application is database bound or file system bound you wont likely notice much of a difference as the time you spend running CIL code or interpreted code is a small portion of your overall CPU consumption.
With Mono 2.8 we significantly improved Mono's web server scalability, but this will not matter if your application does not use or require more than a handful of CPUs. But is incredibly useful for people that are scaling servers under load.
How is your team keeping such a fast pace? Do you get a lot of assistance or documentation for Microsoft. Your rate of feature parity with the MS releases is impressive.
In addition, a big help was the fact that Microsoft open sourced large swats of code in this release (DLR, MWF, OData, LINQ, and a bunch more).