If so, that is a difference from IPv4. Don't block IPs, block subnets. Block the whole /64. It's what you were doing with IPv4 anyway - blocking a whole building / office / etc at once!
That's still no reason to turn IPv6 off in my humble opinion...
Most stuff defaults to bucketing by /64s.
IP blocking is far from ideal, in both versions of IP.. IPv6 makes this no better, or worse.
It's entirely reasonable to say "It works fine without [=zero business value], no need to invest that amount of work.". This makes IPv6 a negative value proposition for many orgs.
I mostly focus on users of VPN services. It's still rare for them to handle IPv6 traffic. So if you have IPv6 connectivity, IPv6 will leak, bypassing the VPN. Unless you have firewall rules, or disable IPv6 while using the VPN.