Imagine giving someone 200 years ago $400B for cancer research; what do you think it would have happen? Do you think they would have found the cure? No. The same thing happens today, $400B may do nothing big for cancer research and what's needed to advance in that area its time; decades (maybe centuries) of advancements in many fields that are not directly related to cancer research but given enough time those advancements will be used together to find a cure (e.g. map the entire DNA; nanorobots, etc)