Of course it makes them angry and it should. These type of operations should be handled with the gravest responsibility and killing dozens of noncombatants just because they're gathered for a wedding, for example, is an outrage and beyond unacceptable. But do you think these operations are happening without the approval of the Pakistani government, or do you think those statements are for domestic consumption?

It's not OK to kill civilians in Pakistan regardless of what the Pakistani government may or may not privately think about it.

But that's not what's happening. Pakistani militants have planned and executed attacks on US citizens in the US and Afghanistan. Bin Laden lived there and coordinated from northern Pakistan for a decade after 9/11. The operations are targeting criminals who have committed and conspired to commit murder, not an indiscriminate campaign of murder against random citizens of Pakistan. Many innocent Pakistani people (and a Pakistani PM) have been killed by these groups. It's not morally cut and dry.

From wikipedia (see above):

"the US policy of considering all military-age males in a strike zone as militants"

In other words: even IF you assume that killing someone because they're "militants" is automatically okay, the people "pulling the trigger" barely ever know who they're killing, yet they retroactively count them as "probably bad enough to be droned".

John Oliver had a good segment on the issue:

https://www.youtube.com/watch?v=K4NRJoCNHIs