Not sure if you meant it like this but redshift estimation comes to my mind. The farther away a galaxy is, the redder it becomes. You can measure the distance (redshift) from galaxy spectra (with MUSE for example) but not from directly HST images. This mapping color -> redshift is called photo-z and was tested with MUSE data in an very famous area observed with HST, the Hubble Ultra Deep field. https://arxiv.org/abs/1710.05062