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Re:Improving Connectomics by an Order of Magnitude by jmrko on Monday July 16, 2018 @04:48PM (#17544949)
One of the authors here; Imaging synapses is really no problem with electron microscopy resolution. In fact, you can see automatically extracted synapses (little spheres) in the video of the blog post, this was done a year earlier already!
Re:Improving Connectomics by an Order of Magnitude by saltcured on Monday July 16, 2018 @10:12PM (#17546794)
Oops, sorry, I have been talking to folks doing en vivo fluorescent imaging and didn't notice that this was electron microscopy!

Not only is the resolution a lot worse for optics, but I understand that the signal to noise ratio is much lower when avoiding destructive imaging methods.