I had read years ago that all the herpes viruses emit RNA strands into the nucleus upon initial infection and conversion of the cell into a "provirus."

This RNA serves to keep the virus latent and quiet, perhaps for years. Only when this suppressive RNA is washed out of the nucleus does replication begin.

The idea was to remove all of this RNA everywhere in a controlled manner while administering acyclovir or another antiviral. I don't know what inaccessible resovoirs remain for the herpes family. The brain would be particularly hard to reach.

Such a treatment might also trigger shingles, mono, and ks all at once if it was too widely targeted or if the antiviral wasn't strong enough.