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Re:Modern Perl: The Book: The (draft) PDF by sigzero on Saturday October 02, 2010 @06:32PM (#1751527)
These folks seemed to have no problem creating a big system in Perl:

http://www.lacunaexpanse.com/

Re:Modern Perl: The Book: The (draft) PDF by elblanco on Saturday October 02, 2010 @09:22PM (#1751828)
The entire backend of www.thinkgeek.com is written in Perl and that's a relatively high volume, big e-commerce site.