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A comment on Thousands Say Kratom Cured Their Addiction, Government Says It’s Another Opioid. Parent comment

Re:Thousands Say Kratom Cured Their Addiction, Government Sa... by JamesBarney on Sunday July 08, 2018 @01:31PM (#17485007)
I don't think it has the same binding affinity as more powerful opiods which reduces it's addictive potential, as well the risk of overdose.
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Re:Thousands Say Kratom Cured Their Addiction, Government Sa... by __blockcipher__ on Sunday July 08, 2018 @04:48PM (#17486123)
It activates mu-opioid quite strongly but not the other receptors as much (I forget their names).

Interestingly, it has a mix of opioid antagonists and agonists. I’m not sure if that specifically is why tolerance doesn’t build aggressively, or if it’s some other MoA like nmda receptor antagonism

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