I've just started using Asana in the last month, the very first thing I noticed was how incredibly slow the interface is to respond. Dragging things around on a board is particularly painful compared to Trello or Github Projects.

I also find it incredibly annoying that when you add a card to a column, it adds it to the top of the column, rather than the bottom.

However, aside from those two annoyances, it does seems to offer a lot of useful functionality.