BTW, in the US, Boulder seems to have some 'cool' companies, and is pretty far from the coast itself.
I am not saying you should rush out of San Fran for Chicago, but if you are considering moving here you should give it serious consideration.
One caveat, for the love of god don't move to the suburbs. They are filled with mid-westerners. scary.
* "Real people" as someone said below. People can be kind of fake and superficial in certain parts of California.
* People in it for the long haul: so many people in places like the Bay Area are not planning to stay there. Indeed, unless you make a lot of money, it can be pretty difficult to stay there if you want things like a family. In any case, people are constantly coming and going, so you tend to be a little bit more guarded/less committed in your dealings with people, whereas elsewhere, people stick around a bit more, so you can get to know them with less fear that they'll be leaving soon.