I would steer clear of .org, .net, or many others...but I think that .tv domains can be a great choice if you're doing something video-related.
.tv is different enough from .org/.com to be memorable, and can be quite descriptive about what you are offering.
On the other hand it seems inevitable that in the long run people will get used to other TLDs, because not every valid business will be able to aquire a good .com-name.