I use a single tab for indentation, and too much exposure to Java and the Eclipse default indentation size (4 spaces per tab) made me used to it. I also find it easier to look at python code indented by 4 spaces per tab. Since I also tend to limit line length to 80 chars, 8-spaces tabs would quickly use up precious space.
Linus disagrees: http://lxr.linux.no/linux+v2.6.35.7/Documentation/CodingStyl...
Still though, my question remains. Is there a particular reason you prefer 4? Does it affect your workflow in any way or does it just 'look better' in the abstract? I'm curious.