These architectural bizarrities exist and have to be dealt with by someone. Of course it is better if that someone isn’t you—if some rust maintainer ports the language to the obscure hardware where the CPU ignores the lower four bits when addressing and presents nice, neat, and performance abstractions for you to use.

But who is going to pay for that effort? If the hardware manufacturer cared enough to to invest a lot in developer tooling it probably wouldn’t have picked such a hostile interface to begin with.