At one point I was highly concerned with lock-in, but I'm becoming less so. in the last 7 or 8 years the companies I've worked for have exclusively used AWS, and prices have come down and stayed competitive. Giving up the platform-independence also allows you to take advantage of platform specific features, which can make development a lot faster.

I still think platform neutrality is a good goal, but I'm starting to view it like I do database neutrality. It's great in theory to be able to swap out postgres with mysql and vice versa, but you miss out on a lot of features of postgres that aren't portable. And in practice, I've never swapped out postgres for something else. Just some thoughts.