The reason why C or Rust are fast is primarily the increase data locality. In java, js or python everything is a pointer. Fetching random parts of memory is expensive therefore if you want to keep the CPU fed with data you need continguous data structures. In theory nothing other than data locality stops JS from being faster than C and the proof is webassemby which gets 50% of the performance of native code which is really impressive considering that webassembly runs inside a sandbox that prevents glaring security issues like bufferoverflows on the stack from rewriting the return address.