The language has some very ugly warts (although ES6+ fixes many things), I find that the quality/maturity/stability of third party libraries lags behind other languages, and the whole build/dev environment best practices is constantly in flux and breaking things all the time. Also Electron, for all it's advantages, is renowned for being a massive resource hog making what is otherwise a fairly fast and efficient language appear horribly slow at times.

That being said, developing in JS today is a lot better than 3-4 years ago, and I suspect that that pattern will continue.